Our goal is the design and implementation of algorithms solving problems in computational biology. Main topics are related to protein evolution and the development of tools for protein design. In many cases, we utilise knowledge-based potentials deduced from large data sets. We offer the following methods and datasets.

 

Web Services

H2r (predicting residues important for protein function based on correlated mutations)
CLIPS-1D (predicting functionally and structurally important residue-positions)
PresCont (predicting protein-protein interfaces)
GCB-Scores (predicting translational efficiency of genes)
for a whole genome(GCB4Genome) or
individual genes (GCB4gene)

 

Software and Datasets

Key2Ann (Replacing database keys with a meaningful annotation)

GO4genome (whole genome phylogeny, source code and Y. pestis dataset)
PresCont (3D structures and MSAs for protein-protein complexes)

 

Additional Tools, developed in cooperation with other groups

SIGI-HMM (Predicting genomic islands, download)
YACOP (Enhanced gene prediction obtained by a combination of existing methods, download)